Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell (usually white blood cells). GM-CSF is a hematopoietic growth factor that functions to stimulate the development of neutrophils and macrophages. Recombinant human GM-CSF is a 14.6 kDa globular protein made up of 128 amino acids.
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